Sherman 2 attack of the tagger
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The proposed technology will increase the safety and efficacy of gene editing by optimizing the precision of editing to correct the disease. The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase II project will be the development of a curative therapy for spinal muscular atrophy using a novel and proprietary precision gene editing technology. This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria. Tooling inserts will be tested across the most common and challenging injection molding plastics. This project will apply advancements in fiber-filled photopolymers (such as ceramic and polymer particle reinforced resins) in combination with magnetically aligned structures to injection mold tools. This Phase II SBIR will apply advancements in 3D printing of fiber-reinforced photopolymers to the injection molding application. This will be used for applications in industries across automotive, aerospace, consumer product goods, and medical devices. The proposed project will develop new tooling for low-volume injection molding applications at strengths and resolutions comparable with machined aluminum at a fraction of the current cost and lead time, providing extra resilience to the supply chain. Unfortunately, injection molding can be a lengthy and wasteful process because molds are designed, machined from metal, and then shipped to an injection molder. The broader impact/commercial potential of this SBIR Phase II project is to lower costs for injection molding, a common method of manufacturing plastic goods.